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Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act. ==Classes== There are three classes of imidazoline receptors:〔 * I1 receptor – mediates the sympatho-inhibitory actions of imidazolines to lower blood pressure, (NISCH or IRAS, imidazoline receptor antisera selected) * I2 receptor – an allosteric binding site of monoamine oxidase and is involved in pain modulation and neuroprotection * I3 receptor – regulates insulin secretion from pancreatic beta cells Activated I1-imidazoline receptors trigger the hydrolysis of phosphatidylcholine into DAG. Elevated DAG levels in turn trigger the synthesis of second messengers arachidonic acid and downstream eicosanoids. In addition, the sodium-hydrogen antiporter is inhibited, and enzymes of catecholamine synthesis are induced. The I1-imidazoline receptor may belong to the neurocytokine receptor family, since its signaling pathways are similar to those of interleukins.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「imidazoline receptor」の詳細全文を読む スポンサード リンク
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